| Year | Date | Historical Events |
| 1965 | Mar 9 | Contract awarded to the Electric Boat Co., Groton, CT. |
| 1966 | Aug 13 | Keel laid down by the Electric Boat Co., Groton, CT. |
| 1968 | Jun 15 | Launched. |
| 1969 | Sep 19 | Commissioned with CDR. George T. Harper, Jr., in command. Following a shakedown cruise in the Caribbean Sea and visits to Roosevelt Roads and San Juan, Puerto Rico, and Frederiksted, St. Croix, Seahorse returned to her home port, Charleston, SC.
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| 1970 | Nov 30 | Seahorse got underway from Charleston, SC. on her first major deployment, in which she operated in the Atlantic and visited Bremerhaven, Germany. |
| 1971 | Feb 14 | Seahorse returned to Charleston, SC. For the next 4 months, Seahorse conducted type training, engaged in air group operations and made final preparations for an extended Mediterranean Sea deployment. |
| | Jun 21 | Departing Charleston on 21 June, she arrived at Rota, Spain, on 2 July and continued to operate in the Mediterranean until 4 October when she headed back to Charleston, SC.
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| 1972 | Jan 24 | Seahorse ran aground and was stranded for two hours while attempting to put to sea from Charleston, SC. After breaking free, she returned to port for repairs. |
| | Feb 9 | Seahorse again set sail for a north Atlantic deployment, visiting Faslane, Scotland. |
| | May 11 | Seahorse returned to Charleston, SC. |
| | Sep 1 | Seahorse departed for the North Atlantic to participate in NATO Exercise "Strong Express," followed by exercises with Great Britain and Canada in October and with the Royal Netherlands Navy in November. |
| | Nov 5 | Seahorse returned to Charleston, SC. |
| 1995 | Aug 17 | Decommissioned and struck from the Naval Register. |
| 1996 | Mar 1 | Seahorse entered the Nuclear Powered Ship and Submarine Recycling Program at the Puget Sound Naval Shipyard, Bremerton, WA., on 1 March 1996 and on 30 September 1996 ceased to exist.
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