| Year | Date | Historical Events |
| 1942 | Oct 30 | Keel laid down by the Electric Boat Co., Groton, CT. |
| 1943 | Jul 11 | Launched by the Electric Boat Co., Groton, CT. |
| | Oct 18 | Commissioned with LCDR. J. W. Crowley in command.
|
| | Dec 20 | Flier reached Pearl Harbor, HI. from New London, CT. and prepared for her first war patrol. |
| 1944 | Jan 12 | FLIER sailed on her 1st war patrol. Damage suffered in a grounding near Midway necessitated her return to the West Coast for repairs. |
| | May 21 | Flier sailed again for action, heading for a patrol area west of Luzon. |
| | Jun 4 | Flier made her first contact attacking a well-escorted convoy for 5 merchantmen. Firing 3 torpedoes at each of 2 ships, she sent a large transport to the bottom and scored a hit on another ship, before clearing the area to evade countermeasures.
|
| | Jun 13 | Flier attacked a convoy of 11 ships, cargo carriers and tankers, guarded by at least 6 escorts. The alert behavior of the escorts resulted in a severe attack on Flier before she could observe what damage she had done to the convoy. |
| | Jun 22 | Flier began a long chase after another large convoy, scoring 4 hits for 6 torpedoes fired at 2 cargo ships. |
| | Jun 23 | Flier scored 3 hits for 4 torpedoes launched against another cargo ship of the same convoy.
|
| | Jul 5 | Flier put in to Fremantle, Australia for refit. |
| | Aug 2 | Flier sailed on her 2nd war patrol, bound for the coast of Indochina via the Lombok Strait, Macassar Strait and Balabac Strait. |
| | Aug 12 | Flier was sunk by a mine in the South China Sea 12 Aug 1944. 78 men lost. 8 men survived, swimming to shore. Numerous others made it out of the boat, but drowned. |