| Year | Date | Historical Events |
| 1921 | Feb 19 | Keel laid down at the Bethlehem Shipbuilding Corp.,Quincy, MA. |
| 1923 | Oct 27 | Launched. |
| 1925 | Feb 16 | Commissioned with LT. A. H. Bateman in command.
|
| | Aug 25 | S-44 departed New London, CT. for Panama. |
| | Sep 5 | S-44 arrived at Coco Solo, Canal Zone. |
| 1927 | Apr 15 | S-44 changed homeport to San Diego, CA. |
| 1930 | Dec 15 | S-44 changed homeport to Pearl Harbor, HI. |
| 1934 | Jan 1 | S-44 changed homeport to San Diego, CA. |
| 1937 | Jan 1 | S-44 changed homeport to Coco Solo, Canal Zone. |
| 1941 | Apr 15 | S-44 proceeded to New London, CT. in preparation for overhaul. |
| | Nov 1 | S-44 arrived at the Philadelphia Naval Shipyard, Philadelphia, PA., for overhaul. |
| 1942 | Jan 7 | S-44 got underway to return to Panama. |
| | Jan 16 | S-44 arrived at Panama. |
| | Mar 1 | S-44 departed Panama for Australia. |
| | Apr 15 | S-44 arrived at Brisbane, Australia. |
| | Apr 25 | S-44 departed on her 1st war patrol. |
| | May 12 | S-44 sank the 5,000 ton salvage vessel, Shoei Maru. |
| | May 23 | S-44 arrived at Brisbane, Australia. |
| | Jun 7 | S-44 departed on her 2nd war patrol. |
| | Jun 21 | S-44 sent the converted gunboat, Keijo Maru, to the bottom. |
| | Jul 5 | S-44 arrived back at Brisbane, Australia. |
| | Jul 24 | S-44 departed Brisbane, Australia on her 3rd war patrol. |
| | Aug 10 | S-44 sighted a convoy of 4 Japanese heavy cruisers. She fired 4 torpedoes and sank the Kako. |
| | Aug 23 | Arrived back at Brisbane, Australia. |
| | Sep 17 | S-44 began her 4th war patrol. |
| | Oct 4 | s-44 damaged a destroyer, then survived an intensive depth charge attack. |
| | Oct 14 | S-44 arrived back in Brisbane, Australia. |
| | Nov 14 | S-44 departed Brisbane, Australia and headed back to the United States. |
| 1943 | Jan 3 | S-44 transited the Panama Canal, then moved across the Caribbean and up the Atlantic seaboard to Philadelphia, PA. |
| | Apr 1 | S-44 underwent overhaul from April to June at the Philadelphia Naval Shipyard, Philadelphia, PA. |
| | Jul 15 | S-44 retransited the Canal enroute to San Diego, CA. and the Aleutian Islands.
|
| | Sep 16 | Arrived at Dutch Harbor in the Aleutian Islands. |
| | Sep 26 | S-44 departed Attu on her last war patrol. |
| | Oct 7 | S-44 was sunk by a Japanese destroyer in the Northern Kuril Islands 7 Oct. 1943. 54 men lost. Two men picked up by Japanese destroyer, repatriated at end of war. |