| Year | Date | Historical Events |
| 1975 | Aug 1 | Contract awarded to the Newport News Shipbuilding and Drydock Co., Newport News, VA. |
| 1977 | May 26 | Keel laid down by the Newport News Shipbuilding and Drydock Co., Newport News, VA. |
| 1979 | Oct 27 | Launched. |
| 1981 | Apr 24 | Commissioned with CDR. J. Allen Marshall in command. Following an initial shakedown cruise, San Francisco joined the Submarine Force, US Pacific Fleet and moved to her homeport at Pearl Harbor, HI.
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| 1982 | Jan 1 | San Francisco completed deployments in 1982, 1985, and 1986 with the U.S. Seventh Fleet and various independent operations in the Pacific in 1986 and 1988 earning the Battle Efficiency "E" for Submarine Squadron Seven in 1985 and 1988.
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| 1989 | Jan 1 | San Francisco entered a Depot Modernization Period at Pearl Harbor, HI. from 1989 to 1990 and then went on to conduct deployments to the Western Pacific in 1992 and 1994. |
| 1994 | Dec 31 | San Francisco was awarded the 1994 Commander Submarine Squadron Seven "T" for excellence in tactical operations and a Meritorious Unit Commendation for the 1994 Western Pacific deployment.
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| 2002 | Dec 18 | San Francisco arrived at her new homeport at Apra Harbor, Guam.
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| 2005 | Jan 8 | San Francisco collided with an undersea mountain about 350 statute miles south of Guam while operating at flank speed and more than 500 feet deep. The collision was so serious that the vessel was almost lost. |
| | Jan 9 | Twenty three crewmen were injured, and Machinist's Mate Second Class Joseph Allen Ashley, 24, of Akron, Ohio, died from head injuries. |
| | Jan 10 | She surfaced and, accompanied by USCGC Galveston Island (WPB-1349), USNS Stockham (T-AK-3017), and USNS Kiska (T-AE-35), as well as MH-60S Knighthawks and P-3 Orion maritime patrol aircraft, arrived in Guam. |
| | Jan 11 | Commander Kevin Mooney, San Francisco’s commanding officer, was reassigned to a shore unit in Guam during the incident investigation. |
| | Jan 11 | (Cont'd.) As the investigation concluded, the Navy found that, despite Mooney's otherwise remarkably good record, "several critical navigational and voyage planning procedures" were not being implemented aboard San Francisco. |
| | Jan 11 | (Cont'd.) Consequently, the Navy relieved Mooney of command, and issued him a nonjudicial letter of reprimand. He was not charged with a crime and was not court-martialed. |
| | Jan 11 | (Cont'd.) Six crew members were also found guilty at their own nonjudicial punishment hearings ("Captain's Mast") of hazarding a vessel and dereliction of duty, and were reduced in rank and given punitive letters of reprimand. |
| | Jan 11 | (Cont'd.) 20 other officers and men received awards, including letters of commendation, the Navy and Marine Corps Achievement Medal, the Navy and Marine Corps Commendation Medal, and the Meritorious Service Medal.
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| | Aug 26 | San Francisco arrived at the Puget Sound Naval Shipyard, Bremerton, WA. for repairs. |
| 2006 | Jun 1 | It was announced that San Francisco's bow section was to be replaced with that of the soon to be retired USS Honolulu (SSN-718) at the Puget Sound Naval Shipyard, Bremerton, WA. |