| Year | Date | Historical Events |
| 1962 | Sep 5 | Contract awarded to the Portsmouth Naval Shipyard, Kittery, ME. |
| 1964 | May 12 | Keel laid down by the Portsmouth Naval Shipyard, Kittery, ME. |
| 1967 | Jun 22 | Launched. |
| 1969 | Oct 11 | Commissioned with CDR. Charles R. Baron in command. |
| 1993 | Mar 20 | Grayling collided with K-407 Borisoglebsk, a Delfin-class Ballistic Missile Submarine commanded by Captain First Rank Andrei Bulgarkov. Reports that Grayling had to be "written off" after this collision are exaggerated. |
| 1996 | Jun 1 | Grayling took part in Exercise TAPON 96, an allied exercise held in the Alboran Sea, Gulf of Cadiz, and the eastern Atlantic Ocean. |
| 1997 | Mar 1 | Grayling was deactivated, and placed "in commission, in reserve". |
| | Mar 8 | Grayling entered the Nuclear Powered Ship and Submarine Recycling Program at the Puget Sound Naval Shipyard, Bremerton, WA., and on 31 March 1998, ceased to exist. |
| | Jul 18 | Decommissioned and struck from the Naval Register. |
| 1998 | Apr 1 | Grayling's sail is now a memorial on the grounds of Portsmouth Naval Shipyard, Kittery ME. Grayling's anchor and chain are also on display as a memorial in downtown Grayling, MI.
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