| Year | Date | Historical Events |
| 1958 | Aug 20 | Keel laid down by Electric Boat Co., Groton, CT. |
| 1959 | Dec 29 | Launched. |
| 1960 | Jul 29 | Commissioned. |
| | Aug 24 | Assigned to SubRon 6, Division 62, she sailed for a 2 month deployment in Eruopean waters, participating in exercises with units of the 6th Fleet and of other NATO navies. |
| 1961 | May 15 | Departed New London after training along the eastern seaborad to cross the Atlantic again for operations which took her into the summer. |
| | Sep 15 | Changed home port to Norfolk, VA. where she remained for the remainder of her career specializing in the development of nuclear submarine warfare tactics. |
| 1963 | Jun 1 | Entered Charleston Naval Shipyard, Charleston, SC. for overhaul. |
| 1964 | Aug 4 | After resuming duty off the eastern coast, she again interrupted that duty to make a transatlantic patrol. |
| 1965 | Mar 1 | Scorpion made a translantic patrol in European waters. |
| 1966 | Feb 1 | Scorpion deployed for Special Operations in European waters. |
| | Sep 1 | Scorpion deployed for Special Operations in European waters. |
| | Dec 1 | Scorpion's Commanding Officer received the Navy Commendation Medal for outstanding leadership, foresight, and professional skill. Other Scorpion officers and crewmen were cited for meritorious achievement.
|
| 1967 | Feb 1 | Entered Norfolk Naval Shipyard for another extended overhaul. |
| | Nov 9 | Commenced Weapons System Accuracy Tests in the Caribbean around Frederiksted, St. Croix |
| | Nov 17 | Pulled in to Frederiksted, St. Croix for a short period ashore. Left on the 19th. |
| | Dec 4 | on the Fourth and the Fifth, conducted Torpedo launching exercises around the Virginia Capes |
| 1968 | Jan 13 | From 13 Jan to the first week of Feb, was a part of the Aged Daddy V execises south of Norfolk. |
| | Feb 15 | Following type training out of Norfolk she got underway for exercises with Task Force 83.4 southeast of Bermuda; acting as a target for surface ships. Finished these exercises on 19 February. |
| | Feb 20 | Participated in HUKEX exercises in the Mid Atlantic. Headed toward the Strait of Gilbralter at the end of these on February 25th. |
| | Feb 27 | Sailed for Rota, Spain to receive supplies and upkeep. |
| | Feb 28 | Scorpion is in Rota, Spain for five days to work on equipment. Left Rota on 5 March, 1968 |
| | Mar 10 | Anchored in harbor of Taranto, Spain. Left on March 12 for Naval Exercise. |
| | Mar 23 | In Augusta Bay, Sicily for Liberty. Left March 30. |
| | Apr 10 | Liberty in Naples, Italy.Tied up to USS Tallahatchie County AVB-2.Left around April 20. |
| | Apr 20 | Back in Naples, Italy for R and R. Left April 28. |
| | May 16 | Just before Midnight of 16 May, Bill Elrod and Joe Underwood left the ship via Navy Tug in Roata Spain to fly back to the United States. |
| | May 22 | From Silent Steel by Stephen Johnson on page 13The Scorpion and it's crew died on May 22, 1968 at precisely 1822 GMT. Fifteen acustic signals over a period of 190 seconds signaled the loss of the submarine. |
| | May 22 | Decommissioned. |
| | May 22 | Shortly after midnight of the 22nd,She indicated her position to be about 50 miles south of the Azores. Her last transmission ended at 0302. Six days later she was reported overdue at Norfolk. 99 men lost. |
| | Jun 5 | After a search was initiated, her crew was delcared "presumed lost". |
| | Jun 30 | Struck from the Naval Register. |
| | Oct 30 | The Navy's oceanographic research ship, MIZAR (T-AGOR-11) located sections of the hull in more then 10,000 feet of water about 400 miles southwest of the Azores. |