| Year | Date | Historical Events |
| 1962 | Nov 1 | Contract awarded to the Newport News Shipbuilding and Drydock Co., Newport News, VA. |
| 1963 | Jul 29 | Keel laid down by the Newport News Shipbuilding and Drydock Co., Newport News, VA. |
| 1964 | Nov 21 | Launched. |
| 1965 | Dec 22 | Commissioned. |
| | Dec 22 | Recommissioned. |
| 1972 | Jul 21 | Lewis and Clark completed conversion of her missile tubes to carry Poseidon C3 missiles instead of the Polaris A3 missiles she had originally been equipped with. |
| | Dec 18 | Lewis and Clark's Gold Crew successfully launched one Poseidon C-3 missile in support of the ship's Demonstration and Shakedown Operation.
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| 1973 | Apr 8 | Lewis and Clark deployed for operational patrol.
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| 1981 | Jun 19 | Lewis and Clark successfully fired four Poseidon C-3 missiles in a Follow-on Operational Test. |
| | Jul 23 | Lewis and Clark began a Poseidon refueling overhaul at the Newport News Shipbuilding and Drydock Co., Newport News, VA.
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| 1985 | Jun 13 | Lewis and Clark successfully launched four Poseidon C-3 missiles in a Follow-on Operational Test.
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| 1991 | Oct 1 | Lewis and Clark was deactivated while still in commission. |
| 1992 | Jun 27 | Decommissioned. |
| | Aug 1 | Struck from the Naval Register. |
| 1995 | Oct 1 | Lewis and Clark began the Navy's Nuclear Powered Ship and Submarine Recycling Program at the Puget Sound Naval Shipyard, Bremerton, WA., and ceased to exist on 23 September 1996.
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| 2008 | Sep 15 | Lewis and Clark's sail and fair-water planes are now on display at the Patriots Point Naval and Maritime Museum in Charleston, SC. Part of a memorial to the officers and men of the Submarine Service that served during the Cold War. |