| Year | Date | Historical Events |
| 1961 | Jul 21 | Contract awarded to the Portsmouth Naval Shipyard, Kittery, ME. |
| 1962 | May 21 | Keel laid down by the Portsmouth Naval Shipyard, Kittery, ME. |
| 1964 | May 12 | Launched. |
| | Dec 19 | Commissioned with CDR. Robert E. Crispin in command of the Blue Crew and CDR. William M. Cossaboom in command of the Gold Crew.
|
| | Dec 30 | Nathanael Greene departed Portsmouth, NH. for shakedown, with her Gold Crew embarked. |
| 1965 | Feb 1 | The Golds Crew was relieved by the Blue Crew. Her shakedown period was followed by availability at Portsmouth, NH. after which, with Blue Crew embarked, departed Portsmouth, NH. for a missile loadout and her initial Polaris missile deterrent patrol.
|
| 1986 | Mar 13 | Nathanael Greene ran aground in the Irish Sea, suffering severe damage to her rudder and ballast tanks. |
| | Dec 15 | Decommissioned. |
| 1987 | Jan 31 | Struck from the Naval Register. |
| 1998 | Sep 1 | Nathanael Greene entered the Navy's Nuclear Powered Ship and Submarine Recycling Program at thew Puget Sound Naval Shipyard, Bremerton, WA., and on 20 October 2000, she ceased to exist.
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| 2000 | Oct 20 | Nathanael Greene's sail has been restored and is now on display in Port Canaveral, Florida as a memorial to the original 41 fleet ballistic missile submarines. |