| Year | Date | Historical Events |
| 1957 | Dec 31 | Contract awarded to the Electric Boat Co., Groton, CT. |
| 1958 | Nov 1 | Keel laid down by the Electic Boat Co., Groton, CT. |
| 1959 | Jun 9 | Launched. |
| | Dec 30 | Commissioned with Commander James B. Osborn in command of the Blue crew and Commander John L. From, Jr. in command of the Gold crew.
|
| 1960 | Jun 28 | George Washington sailed from Groton, CT. to Cape Canaveral, FL., where she loaded two Polaris missiles. |
| | Jul 20 | George Washington successfully launched the first Polaris missile from a submerged submarine. |
| | Jul 30 | George Washington then embarked her Gold crew, and she launched two more missiles while submerged. |
| | Aug 30 | Shakedown for the Gold Crew ended at Groton, CT. |
| | Oct 28 | George Washington got underway from Groton, CT. for the Naval Weapons Station Charleston, SC., to load her full complement of 16 Polaris missiles. |
| | Oct 28 | (Cont'd.) There she was awarded the Navy Unit Commendation, after which her Blue crew took over and embarked on her first deterrent patrol.
|
| 1961 | Jan 21 | George Washington completed her first patrol after 66 days of submerged running, and put in at New London, CT.. |
| | Feb 14 | The Gold crew took over and departed on her next patrol. |
| | Apr 25 | George Washington entered Holy Loch, Scotland. Four years after her initial departure from Groton, CT., she put in to refuel, having cruised some 100,000 miles. George Washington was shifted to the Pacific Fleet and was home-ported at Pearl Harbor, HI. |
| 1981 | Apr 9 | George Washington surfaced underneath the Nissho Maru in the East China Sea about 110 miles south-southwest of Sasebo, Japan. The 2350-ton Japanese freighter Nisho Maru sank in about 15 minutes. Two Japanese crewmen were lost; thirteen were rescued. |
| 1985 | Jan 24 | Decommissioned. |
| 1986 | Apr 30 | Struck from the Naval Register and was scheduled for disposal through the Ship-Submarine Recycling Program at Puget Sound Naval Shipyard, Bremerton, WA. |
| 1998 | Sep 30 | Recycling of the ship was completed on 30 September 1998. Her sail was removed prior to disposal and now resides at the Submarine Force Library and Museum, New London, CT. |