| Year | Date | Historical Events |
| 1944 | Jan 12 | Keel laid down by the Manitowoc Shipbuilding Co., Manitowoc, WI. |
| | May 28 | Launched. |
| | Oct 14 | Commissioned with CDR. F. D. Latta in command.
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| | Dec 3 | After trial tests and training in Lake Michigan, Lagarto entered a floating drydock, and was floated down the Mississippi River. |
| | Dec 5 | Lagarto departed New Orleans, LA. for the Pacific. |
| 1945 | Feb 7 | Lagarto sailed from Pearl Harbor, HI. for her maiden war patrol in waters around the Nansei Shoto. |
| | Feb 13 | In a coordinated attack with Haddock (SS-231) and Sennet (SS-408), she engaged four heavily armed picket boats in a gun battle, sank two, and damaged the others. |
| | Feb 24 | Lagarto sank a small freighter, Tatsumono Maru off Bungo Suido and not long afterward spotted a Japanese submarine. She torpedoed and sank enemy submarine I-71 in a day periscope attack. |
| | Mar 20 | Lagarto arrived at Subic Bay, Philippine Islands. |
| | Apr 12 | Lagarto departed Subic Bay for the South China Sea and late in April was directed to patrol in the Gulf of Siam, where Baya (SS-318) joined her 2 May. |
| | May 4 | Baya tried to contact Lagarto and she made no reply. Japanese records state that during the night of 3-4 May, mine layer Hatsutaka attacked a U.S. submarine in that location, it is presumed that Lagarto perished in battle with all hands. 85 men lost.
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