| Year | Date | Historical Events |
| 1942 | Mar 20 | Keel laid down by the Portsmouth Naval Shipyard, Kittery, ME. |
| | Jul 20 | Launched. |
| | Oct 1 | Commissioned with LCDR. William N. Wylie in command. Following further yard work and fitting out, Scorpion conducted shakedown operations off the Southern New England coast during January 1943. |
| 1943 | Feb 25 | Scorpion transited the Panama Canal. |
| | Mar 24 | Scorpion arrived at Pearl Harbor, HI. |
| | Apr 5 | Scorpion departed Pearl Harbor, HI. on her 1st war patrol, a hunting and mining mission off the East Coast of Honshu. |
| | Apr 19 | Scorpion reached the mining area near Nakaminato. During the afternoon, she reconnoitered the coast; and, in the evening, she planted her naval mines; then retired to deep water. |
| | Apr 20 | Scorepion sank her first enemy ship, the 1,934 ton converted gunboat, Meji Maru No. 1. |
| | Apr 21 | Scorpion sank her first sampan with gunfire. |
| | Apr 22 | Scorpion destroyed 3 more sampans with gunfire and continued North, toward Kinkasan To.
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| | Apr 27 | Scorpion sank the 6,380 ton merchant vessel Yuzan Maru. |
| | Apr 29 | Scorpion sighted and engaged a 100 ton patrol vessel, which she left burning to the waterline. |
| | Apr 30 | Scorpion stalked, fired on, and finally torpedoed and sank a 600 ton patrol ship. During the fight, however, Scorpion received her first casualty. LCR. R. M. Raymond, on board as prospective Commanding Officer, was hit and killed by gunfire. |
| | May 8 | Scorpion arrived at Pearl Harbor, HI. |
| | May 29 | Scorpion departed Pearl Harbor, HI. on her 2nd war patrol. |
| | Jun 2 | Scorpion refueled at Midway Island. |
| | Jun 21 | Scorpion arrived off Takara Jima in the Tokara Gunto. |
| | Jun 28 | Scorpion shifted her hunt to the Yellow Sea. |
| | Jun 30 | Scorpion was off the Shantung Peninsula. |
| | Jul 3 | Scorpion fired torpedoes at a 5 freighter convoy. Postwar examination of Japanese records show that Scorpion scored 5 hits and sank the 3,890 ton freighter, Anzan Maru, and the 6,112 ton passenger-cargo ship Kokuryu Maru.
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| | Jul 26 | Scorpion arrived back at Pearl Harbor, HI.,underwent repairs, conducted training exercises. |
| | Oct 13 | Scorpion departed Pearl Harbor, HI. on her 3rd war patrol. |
| | Oct 17 | After touching at Midway Island, Scorion headed for the Mariana Islands, where she reconnoitered Pagan Island and Agrihan Island on 25 October and 26 October, and Farallon de Pajoras on 1 November and 2 November. |
| | Nov 13 | Scorpion sighted a freighter and a tanker escorted by 3 warships. Firing her torpedoes, she scored on the oiler, which went dead in the water. One of the escorts dropped depth charges, then rejoined the formation. |
| | Dec 5 | Scorpion arrived at Pearl Harbor, HI. |
| | Dec 29 | Scorpion departed Pearl Harbor, HI. on her 4th and last war patrol. Her assigned area was in the Northern East China Sea and Yellow Sea.
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| 1944 | Jan 3 | Scorpion refuled at Midway Island. |
| | Jan 5 | Scorpion was lost with all hands.76 men lost. Sunk by possible Japanese mine in the Yellow Sea off China. |