| Year | Date | Historical Events |
| 1941 | Dec 8 | Keel laid down by the Portsmouth Naval Shipyard, Kittery, ME. |
| 1942 | May 30 | Launched. |
| | Jul 30 | Commissioned with CDR. F. W. Fenno, Jr., in command. Following shakedown out of New London, CT., Runner departed the East Coast in late 1942.
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| 1943 | Jan 10 | Runner arrived at Pearl Harbor, HI. via the Panama Canal. |
| | Jan 18 | Runner departed on her 1st war patrol in the area between Midway Island and the Palau Islands. 5 Japanese cargo ships were torpedoed on this patrol, but none was confirmed as being sunk. |
| | Mar 7 | Runner returned to Pearl Harbor, HI. for overhaul after receiving damage from an aerial bomb on her 1st war patrol. |
| | Apr 1 | Runner departed on her 2nd war patrol. Runner's primary mission was to lay a minefield off Pedro Blaneo Rock. Successful in this mission, Runner proceeded to Hainan Straits off the Chinese mainland. |
| | May 6 | Runner returned to Midway Island. |
| | May 27 | Runner departed Midway for the Kurile Island chain and waters off northern Japan. No report was heard from her. She sank the cargo ship Seinan Maru on 11 June in Tsugaru Strait off Hokaido, aud the passenger-cargo ship Shinryu Maru on 26 June. |
| | Jul 1 | Runner was declared overdue and presumed lost in July 1943 |
| | Oct 30 | Runner was struck from the Naval Register. |
| | Oct 30 | Struck from the Naval Register |