| Year | Date | Historical Events |
| 1943 | Mar 17 | Keel laid down by the Electric Boat Co., Groton, CT. |
| | Nov 28 | Launched. |
| 1944 | Mar 29 | Commissioned with LCDR. A. L. Becker in command.
|
| | Jun 3 | Cobia arrived at Pearl Harbor, HI. fom New London, CT. |
| | Jun 26 | Cobia put to sea on her 1st war patrol, bound for the Bonin Islands. |
| | Jul 13 | Cobia sank a Japanese freighter. |
| | Jul 17 | Cobia sank a Japanese freighter. |
| | Jul 18 | Cobia sank a Japanese freighter. |
| | Jul 20 | Cobia sank three small armed ships in a running gun battle. One of them rammed Cobia, causing minor damage, but she continued her mission. |
| | Aug 5 | Cobia sank a converted yacht of 500 tons, one of whose survivors she rescued as her first prisoner of war.
|
| | Aug 14 | Cobia returned to Majuro. |
| | Sep 6 | Cobia sailed into the Luzon Straits for her 2nd war patrol. A mission punctuated again and again by attacks by Japanese aircraft. |
| | Oct 22 | Cobia rescued two survivors of a Japanese ship previously sunk by one of Cobia's sisters. |
| | Nov 5 | Cobia put into Fremantle, Australia for refit. |
| | Nov 30 | Cobia cleared on her 3rd war patrol. Sailing into the South China Sea, she reconnoitered off Balabac Strait between 12 December and 8 January 1945. |
| 1945 | Jan 14 | Cobia sank the minelayer Yurishima off the southeast coast of Malay. Surfacing to photograph her sinking victim, Cobia was driven under by a Japanese bomber. |
| | Jan 15 | Cobia rescued two Japanese from a raft on which they had been adrift 40 days.
|
| | Jan 24 | Cobia returned to Fremantle, Australia for refit. |
| | Feb 18 | Cobia sailed to the Java Sea for her 4th war patrol. |
| | Feb 26 | Cobia engaged two sea trucks, one of which resisted with machinegun fire which killed one of Cobia's crew and damaged her radar equipment. After sinking both sea trucks, Cobia interrupted her patrol for repairs. |
| | Mar 4 | Cobia returned to Fremantle, Australia for repairs. |
| | Mar 8 | Cobia returned to the Java Sea. |
| | Apr 8 | Cobia rescued seven men, the surviving crew of a downed Army bomber.
|
| | Apr 15 | Cobia replenished at Subic Bay, Philippine Islands. |
| | May 9 | Cobia put out for the Gulf of Siam and her 5th war patrol. |
| | May 14 | Cobia attacked a cargo ship, but was driven deep by depth charges hurled by a minesweeper. |
| | Jun 8 | Cobia contacted a tanker convoy, and sank both a tanker and the landing craft Hakusa. |
| | Jun 18 | Cobia returned to Fremantle, Australia for refit. |
| | Jul 18 | Coia sailed for her 6th and final war patrol. After landing intelligence teams along the coast of Java, Cobia sailed to act as lifeguard during air strikes on Formosa until the end of hostilities. |
| | Aug 22 | Cobia returned to Saipan, Mariana Islands. |
| 1946 | May 22 | Decommissioned at New London, CT. and placed "In Reserve". |
| 1951 | Jul 6 | Recommissioned, Cobia trained reservists and Submarine School students at New London, CT. |
| 1953 | Oct 29 | Cobia was placed "In Commission, In Reserve" at the Portsmouth Naval Shipyard, Kittery, ME. |
| 1954 | Mar 19 | Decommissioned at New London, CT. and placed "Out of Commission, In Reserve". |
| 1970 | Jul 1 | Struck from the Naval Register. |
| | Aug 17 | Cobia is a museum boat at Manitowoc, WI. |