| Year | Date | Historical Events |
| 1919 | Apr 16 | Keel laid down by the Bethlehem Shipbuilding Corp., Quincy, MA. |
| 1922 | Sep 20 | Launched. |
| 1923 | Dec 13 | Commissioned with LT. Kemp C. Christian in command.
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| 1924 | Mar 1 | Following shakedown exercises off the Southern New England coast, S-28 moved South in March 1924 to join Submarine Division (SubDiv) 11, in the final exercises of that year's winter maneuvers in the Caribbean. |
| | Apr 1 | S-28 returned to New London, CT. with her division and commenced local exercises which occupied the remainder of the year. |
| 1925 | Dec 1 | With the winter of 1925, S-28 moved South again. Transited the Panama Canal, and, after the conclusion of Fleet Problem V—conducted in the vicinity of Guadalupe Island—she arrived in the Hawaiian Islands for a month's stay. (Exact date unknown) |
| 1926 | Jun 1 | In June, she moved east, to San Diego, where her division replaced another which had been transferred to the Asiatic Fleet. (Exact date unknown)
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| 1931 | Jan 15 | S-28 operated off Southern California deploying for Fleet problems in the Panama Canal area in 1926 and 1929; for summer maneuvers in Hawaiian waters in 1927 and 1930, and for regularly scheduled overhaul periods at the Mare Island Naval Shipyard. |
| | Feb 15 | S-28 departed the West Coast for Hawaii. |
| | Feb 23 | S-28 arrived at Pearl Harbor, HI. whence she operated for the next eight and one half years. |
| 1939 | Jun 1 | S-28 was transferred back to San Diego, CA., where she was based until after the United States entered World War II.
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| 1941 | Dec 7 | S-28, then a unit of SubDiv 41 was undergoing overhaul at the Mare Island Naval Shipyard, Vallejo, CA. |
| 1942 | Jan 22 | S-28 returned to San Diego, CA. where she resumed her prewar training activities for the Underwater Sound Training School. She continued that duty into the spring, then was ordered North, to the Aleutians. |
| | May 20 | S-28, with other submarines of her division, departed San Diego, CA. |
| | May 25 | S-28 topped off with fuel at Port Angeles, WA., then continued on toward the newly established submarine base at Dutch Harbor, Alaska. |
| | May 29 | As preparations were made to minimize a two-pronged Japanese thrust against Midway and the Aleutians, the S-boats were directed to proceed to their stations, bypassing Dutch Harbor.
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| | Jun 12 | S-28 arrived at Dutch Harbor. Refueled, took on provisions and headed West to resume her war patrol.
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| | Jun 17 | After a two-day storm, S-28 sighted Kiska and set a course to intercept enemy shipping between there and Attu. |
| | Jun 18 | S-28 fired on her first enemy target, a destroyer, and was in turn attacked. Eight hours later, sounds of the destroyer's search faded out to the South. |
| | Jun 28 | S-28 moored in Dutch Harbor and commenced refit. |
| | Jul 15 | S-28 got underway and again headed for the Kiska area on her 2nd war patrol. |
| | Jul 18 | S-28 reconnoitered Semisopochnoi, then moved on to Segula. Finding no signs of Japanese activity, she continued Westward. |
| | Jul 20 | S-28 was ordered to take station on an 85-mile circle from Sirius Point prior to sunrise on the 22d, at which time the enemy's facilities on Kiska were to be bombarded. |
| | Jul 30 | S-28 was ordered back into the Kiska area. |
| | Aug 18 | Having been unable to close any of the targets sighted during the latter part of her patrol, S-28 returned to Dutch Harbor.
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| | Sep 16 | On her third war patrol, S-28 returned to the Kiska area. She operated to the North of the island until the 25th. Then, with the discovery of the enemy's development of Gertrude Cove on Vega Bay, she shifted to the island's Southern shore. |
| | Sep 16 | On her third war patrol, S-28 returned to the Kiska area. She operated to the north of the island until the 25th.Then, with the discovery of the enemy's development of Gertrude Cove on Vega Bay, she shifted to the island's southern shore. |
| | Oct 7 | S-28 turned toward Unalaska. |
| | Oct 10 | As S-28 prepared to fire on an unidentified vessel, a ground in her fire control circuits caused an accidental firing from the No. 1 tube.
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| | Oct 10 | S-28 arrived back in Dutch Harbor, whence she headed for home. |
| | Oct 23 | S-28 arrived in San Diego,CA. and provided training services for the Sound School and for the Amphibious Forces Training Group from 26 Oct. to 13 Nov. Then, during an overhaul, she received a fathometer, a Kleinschmidt distilling unit, and SJ radar. |
| | Dec 9 | S-28 again sailed North. |
| | Dec 21 | S-28 arrived at Dutch Harbor, Alaska. |
| | Dec 27 | S-28 departed on her 4th war patrol. |
| 1943 | Jan 3 | S-28 crossed the International Date Line. |
| | Jan 5 | S-28 entered her assigned area in the Northern Kurils. Moving down the Paramushiro coast, she patrolled in Onekotan Strait, then headed North again. |
| | Jan 20 | S-28 passed Shumushu, whence she set a course for the Aleutians.
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| | Feb 6 | During her 5th war patrol, S-28 remained in the Western Aleutians, patrolling across the Attu-Buldir-Sirius Point route and along the coast of Attu, particularly off Holtz Bay, Chichagof Harbor, and Sarana Bay. |
| | Feb 28 | On her return to Dutch Harbor, S-28 was ordered South. |
| | Mar 4 | S-28 got underway for Esquimalt, B.C., where she conducted sound tests and antisubmarine warfare exercises with Canadian Navy and Air Force units. She then continued on to the Puget Sound Navyal Shipyard for overhaul and superstructure modification work. |
| | Jun 27 | S-28 started back to Alaska. |
| | Jul 13 | S-28 departed Dutch Harbor, Alaska to return to the Northern Kurils for her 6th war patrol.
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| | Aug 14 | S-28 headed East. |
| | Aug 16 | S-28 moored in Massacre Bay, Attu, and commenced refit.
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| | Sep 8 | S-28 departed the Western Aleutians to return to the Northern Kurils. |
| | Sep 13 | S-28 entered her patrol area. |
| | Sep 15 | Severe smoking and sparking from S-28's port main motor necessitated fourteen hours of repair work. |
| | Sep 16 | S-28 transited Mushiru Kaikyo. |
| | Sep 19 | S-28 closed a freighter off the island of Araito. Her torpedoes missed. The "freighter" turned and within minutes had delivered the first two depth charges of a ten-minute attack. The Japanese ship searched the area for an hour, then departed. |
| | Sep 19 | S-28 reloaded and continued her patrol. She contacted a second unescorted enemy vessel. She fired a spread of 4 torpedoes.The target took on a 30° list and began to go down by the bow. The 1,368 ton converted gunboat Katsura Maru No.2 sank. |
| | Oct 5 | S-28 moved through Onekotan Strait and continued her patrol on the Pacific side of the Kurils. |
| | Oct 10 | A serious personnel injury occurred, and an appendicitis case developed. S-28 turned toward Attu one day ahead of schedule.
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| | Oct 13 | S-28 moored at Attu. |
| | Oct 14 | S-28 departed for Dutch Harbor, Alaska. |
| | Nov 1 | S-28 headed South to Hawaii. |
| | Nov 15 | S-28 arrived at Pearl Harbor, HI., and after overhaul, commenced training duty. For the next seven months, she remained in Hawaiian waters, providing training services. |
| 1944 | Jul 3 | S-28 began training operations off Oahu with the Coast Guard cutter Reliance. |
| | Jul 4 | Brief contact with S-28 was made and lost. All attempts to establish communications failed. A Court of Inquiry was unable to determine the cause of the loss of S-28. 50 men lost. |